Life, death and drama at 20,000 feet, SKYMED weaves together intense character journeys and high-stakes medical rescues, as we follow the triumphs, heartbreaks and tribulations of budding nurses and pilots flying air ambulances in remote Northern Canada. They're all in over their heads, and on their own, with no one to rely on but each other.

　　故事描述莱恩（吉诺亚拿尼亚 饰）的妹妹在几个月前失踪了，他认为她失踪的原因是玩了网路上流传的“电梯游戏”，传说只要照着特定步骤操作电梯，就可以前往另一个次元。为了找到妹妹，莱恩说服他的朋友们一同进行电梯游戏，此举却为他们招来无法挽回的后果……